Elizabeth W. Howerth, DVM, PhD

Department of Veterinary Pathology
College of Veterinary Medicine
University of Georgia
Athens, GA 30602-7388

Phone: (706) 542-5833
FAX: (706) 542-5828
EMAIL: HOWERTH@UGA.EDU
Professor, DVM (1978) Michigan State University, PhD (1986) The University of Georgia, Diplomate of the American College of Veterinary Pathologists
Research Interests:  Viral, ehrlichial, and protozoal diseases of wildlife, hoofed stock, birds, and fish; survivin; apoptosis; Helicobacter gastritis; feline bartonellosis
Teaching: Neuropathology, respiratory pathology, hemostasis
Dr. Howerth is primarily interested in the pathogenesis of bluetongue and epizootic hemorrhagic disease in deer, cattle, and sheep. Morbidity and mortality due to these viruses varies greatly between susceptible species; likely explanations for this variation that have been or are currently being investigated include species differences in hemostasis, immune and cytokine responses, variation in endothelial infection, monocyte-endothelium interactions, and deer genetics. She also studies the pathogenesis and epizootiology of vesicular stomatitis and duck plague, and is a member of a team investigating the role of wildlife in the epizootiology of various tick-borne diseases, including those due to Borrelia burgdorferi and B. lonestari, Ehrlichia chaffeensis, and Anaplasma phagocytophilum. , Additional current studies are: the pathogenesis and diagnosis of uronemiasis in fish, survivin expression in canine and feline cancer, the pathogenesis of West Nile virus infection in wild birds, epizootiology and clinical significance of Helicobacter gastritis in domestic and wild carnivores, and feline bartonellosis.
Selected Publications:

Howerth EW, Stallknecht DE, Dorminy M, Pisell T, Clarke GR. Experimental vesicular stomatitis in swine: effects of route of inoculation and sterioid treatment. J Vet Diagn Invest 9: 136-142, 1997

Quist CF, Howerth EW, Stallknecht DE, Brown J, Pisell T, Nettles VF. Host defense responses associated with hemorrhagic disease in white-tailed deer. J Wild Dis 33: 584-599-1997.

Abdy MJ, Howerth EW, Stallknecht DE. Experimental infection of calves with epizootic hemorraghic disease virus. AJVR 60: 621-626, 1999.

Stallknecht DE, Perzak DE, Bauer LD, Murphy MD, Howerth EW. Contact transmission of vesicular stomatitis virus New Jersey in pigs. Am J Vet Res 62: 516-520, 2001.

Davidson WR, Lockhart JM, Stallknecht DE, Howerth EW, Dawson JE, Rechav Y. Persistent Ehrlichia chaffeensis infection in white-tailed deer. J Wildl Dis 37: 538-46, 2001.

Cornish TE, Stallknecht DE, Brown CC, Seal BS, Howerth EW. Pathogenesis of experimental vesicular stomatitis (New Jersey serotype) infection in the deer mouse (Peromyscus maniculatus). Vet Pathol. 38: 396-406, 2001. Howerth EW, Green CE, Prestwood AK. Experimental bluetongue virus infection in white-tailed deer: Coagulation, clinicopathologic and gross pathologic changes. Am J Vet Res 49:1906-1913, 1988.

Howerth EW, Tyler DE. Experimental bluetongue virus infection in white-tailed deer: Ultrastructural findings. Am J Vet Res 49:1914-1922, 1988.

Luttrell MP, Nakagaki K, Howerth EW, Stallknecht DE, Lee KA. Experimental infection of Borrelia burgdorferi in white-tailed deer. J Wildl Dis 30:146-154, 1994.

Dawson JE, Stallknecht DE, Howerth EW, Warner C, Beggie K, Davidson WR, Lockhart JM, Nettles VF, Olson JG, Childs JE. Susceptibility of white-tailed deer (Odocoileus virginianus) to infection with Ehrlichia chaffeensis, etiologic agent of human ehrlichiosis. J Clin Microbiol 32:2725-2728, 1994.

Clarke GR, Stallknecht DE, Howerth EW. Experimental infection of swine with a sandfly (Lutzomyia shannoni) isolate of vesicular stomatitis virus, New Jersey serotype. J Vet Diagn Invest 8:105-108, 1996.

Howerth EW, Stallknecht DE, Dorminy M, Pisell T, Clarke GR. Experimental vesicular stomatitis in swine: effects of route of inoculation and steroid treatment. J Vet Diagn Invest 9: 136-142, 1997

Quist CF, Howerth EW, Stallknecht DE, Brown J, Pisell T, Nettles VF. Host defense responses associated with hemorrhagic disease in white-tailed deer. J Wildl Dis 33: 584-599, 1997.

Quist CF, Howerth EW, Bounous DI, Stallknecht DE. Cell-mediated immune response and IL-2 production in white-tailed deer infected with hemorrhagic disease viruses. Vet Immuno Immunopath 56: 283-297, 1997.

Stallknecht DE, Howerth EW, Kellogg ML, Quist CF, Pisell T. In vitro replication of epizootic hemorrhagic disease and bluetongue viruses in white-tailed deer peripheral blood mononuclear cells and virus-cell association during in vivo infections. J Wildl Dis 33: 574-583, 1997.

Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Howerth EW. Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. J Clin Microbiology 35: 1681-1686, 1997.

Abdy MJ, Howerth EW, Stallknecht DE. Experimental infection of calves with epizootic hemorrhagic disease virus. AJVR 60:621-626, 1999.

Stallknecht DE, Howerth EW, Reeves CL, Seal BS. Potential for contact and mechanical vector transmission of vesicular stomatitis virus New Jersey in pigs. AJVR 60:43-48, 1999.

Stallknecht DE, Perzak DE, Bauer LD, Murphy MD, Howerth EW. Contact transmission of vesicular stomatitis virus New Jersey in pigs. Am J Vet Res 62:516-520,2001.

Varela AS, Luttrell MP, Howerth EW, Moore VA, Davidson WR, Stallknecht DE, Little SE. First culture isolation of Borrelia lonestari, putative agent of southern tick-associated rash illness. J Clin Microbiol.42:1163-9, 2004.

Davidson WR, Lockhart JM, Stallknecht DE, Howerth EW, Dawson JE, Rechav Y. Persistent Ehrlichia chaffeensis infection in white-tailed deer. J Wildl Dis 37:538-46, 2001

Cornish TE, Stallknecht DE, Brown CC, Seal BS, Howerth EW. Pathogenesis of experimental vesicular stomatitis virus (New Jersey serotype) infection in the deer mouse (Peromyscus maniculatus). Vet Pathol.38:396-406, 2001.

Howerth EW, Mead DG, Stallknecht DE. Immunolocalization of vesicular stomatitis virus in black flies (Simulium vittatum). Ann N Y Acad Sci. 2002 Oct;969:340-5.

Mead DG, Howerth EW, Murphy MD, Gray EW, Noblet R, Stallknecht DE. Black fly involvement in the epidemic transmission of vesicular stomatitis New Jersey virus (Rhabdoviridae: Vesiculovirus). Vector-Borne and Zoonotic Diseases. 4:351-359, 2004.

Howerth EW, Pargavantzas GS, Stallknecht DE. Replication of epizootic haemorrhagic disease and bluetongue viruses in DH82 cells. Vet. Ital 40:520-524, 2004.

Johnson ME, Howerth EW. Survivin: A bifunctional inhibitor of apoptosis protein. Vet Pathol 41:599-607, 2004.

Murphy MD, Howerth EW+, Maclachlan NJ, Stallknecht DE. Genetic variation among epizootic hemorrhagic disease viruses in the southeastern United States: 1978-2001. Infect Genet Evol. 5:157-65, 2005.
Updated 05/13/05
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