Education:

• 1991 BS  Duke University
• 1995 MLS  North Carolina State Univ.
• 1999  DVM  North Carolina State Univ.
• 2002 MS Purdue University
• 2008 PhD  Cornell University
• 2002 Diplomate - American College of Veterinary Pathologists

Research Interests:

• Immunomodulatory effects of mycobacterial cell wall lipids
• Pathogenesis of granulomatous diseases
• Intramacrophagic bacterial survival
• Animal models of granulomatous diseases

Selected Publications:

1. Bowdish, D.M.E.*, Sakamoto, K*, Kim, M., Kroos, M., Mukhopadhyay, S., Leifer, C.A., Tryggvason, K, Gordon, S., and D.G. Russell.  MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog 5(6):e1000474. Epub 2009 
   * Equal authorship



2. Sakamoto, K., Geisel, R.E., Kim, M., Smiley, S., Cooper, A.M., Russell, D.G. and E.R. Rhoades.  Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate in vivo but is not required for cell recruitment or cytokine response.  Submitted.

3. Van de Walle, G., Sakamoto, K. and N. Osterrieder.  (2008). CCL3 and herpesvirus chemokine-binding protein gG modulate pulmonary inflammation and virus replication.  J Virol. 82(4):1714-22.

4. Geisel, R.E., Sakamoto, K., Russell, D.G. and E.R. Rhoades. (2005).  In vivo activity of released mycobacterial cell wall lipids is due principally to trehalose mycolates. J Immunol. 174(8):5007-15.

5. Khader, S.A., Pearl, J.E., Sakamoto, K., Gilmartin, L., Jelly-Gibbs, D.M., Ghilardi, N., deSauvage, F. and A.M. Cooper. (2005). IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensible for protection and antigen-specific IFN-g responses if IL-12p70 is available. J Immunol. 175():788-95.

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