Histopathology findings include signs of severe hemolysis: liver with enlarged sinusoids full of blood, degeneration of hepatocytes and plenty of bile pigment (photo: orange-brown pigment) within the biliary system. |
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There are variable degrees of hemoglobinuric nephrosis. At the left, some kidney tubules are filled with hemoglobin casts. |
In the brain on the left, capillaries are filled with erythrocytes and there is perivascular edema. With special staining (Giemsa), the erythrocytes each have Babesia organisms within them. |
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