Histopathologic Findings

Infection with Leishmania is typically demonstrated by identification of the amastigote stage of the parasite within macrophages. This can be achieved through biopsies from a wide variety of tissues or aspirates from lymph nodes or bone marrow stained by Giemsa. The amastigotes, which are approximately 2 micrometers in diameter, is usually found within macrophages and other phagocytic cells.

Necropsy Findings

Upon necropsy, findings may include severe emaciation, and enlargement of the liver, spleen, and lymph nodes. Skin lesions and overgrowth of the claws (onychogryphosis) are often observed. In most cases, the bone marrow is hyperplastic. Examination of the kidneys may reveal a pale cortex.