| Research
Interests: Neuropathogenesis of rabies, Functional genomics and proteomics, Development of anti-viral vaccines, monoclonal antibodies, and agents, and Regulation of rabies virus transcription and replication.
Teaching: Virology and Viral Pathogenesis
Dr. Fu has found that attenuated rabies virus activates, but pathogenic rabies virus evades, the host innate immune responses including activation of IFN pathways, induction of inflammation and apoptosis. He has further found that evasion of the host immune responses of the pathogenic virus is due to restriction of the G protein expression.
In addition, Dr. Fu’s laboratory discovered that phosphorylation of rabies virus nucleoprotein plays an important role in regulation of rabies virus transcription and replication. He has created infectious virus clones with mutation at the phosphorylation site. These mutants have been used in his laboratory for the study of rabies virus biology and pathogenesis, and for the development of avirulent rabies virus vaccines.
Dr. Fu’s Laboratory
Support: Dr. Fu’s research is supported by funding from National Institutes of Health, Center for Disease Control and Prevention
Selected Publications (from a total of 72):
Li, X., Fu, Z. F., Alvarez, R., Tripp, R.A. 2006. Respiratory Syncytial Virus Infects Neuronal Cells and Processes that Innervate the Lung by a RSV G Protein Dependent Process. J. Virol. 80:537-40.
Sarmento, L., Li, X., Howerth, E., Jackson, A. C., Fu, Z. F. 2005. Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the CNS of mice. J. NeuroVirol. 11:571-81.
Zhang, Y-Z., Xiong, C-L., Xiao, D-L., Jiang, R-J., Wang, Z-X., Zhang, L-Z., Fu, Z. F. 2005. Human Rabies in China in the past 54 years. EID, 11:1983-1984.
Wang, Z.W., Wang, Y, Sarmento, L., Li, E.X., Dhingra, V., Tseggai, T., Jiang, B., Fu, Z. F. 2005. Pathogenic rabies virus evades, while attenuated rabies virus activates, the host innate immune responses in the CNS. J. Virol. 79:12554-12565.
Dhingra, V., Li,Q., Allison, A. B., Stallknecht, D. E., Fu Z. F. 2005. Proteomic Profiling and Neurodegeneration in West-Nile-Virus-Infected Neurons. J. Biomed. Biotech. 3:271-179.
Li, X., Samento, L., Fu, Z. F. 2005. Degenerative Changes of Mouse Neuronal Processes after Rabies Infection. J. Virol. 79:10063-10068.
Fu, Z.F., Jackson, A.C. 2005. Neuronal dysfunction and death in rabies virus infection. J. NeuroVirol. 11:101-106.
Liu, P., Yang, J., Wu, X., and Fu, Z.F. 2004. The interactions amongst rabies virus nucleoprotein, phosphoprotein, and the genomic RNA in virus-infected and transfected cells. J Gen Virol ; 85: 3725-3734.
Alanazi, F., Fu, Z.F, Lu, D.R. 2004. Effective transfection of rabies DNA vaccine in cell culture using an artificial lipoprotein carrier system. Pharm. Res. 21:675-682.
Wu X, Lei X, Fu Z.F. 2003. Rabies virus nucleoprotein is phosphorylated by cellular casein kinase II. Biochem. Biophysic. Res. Comm. 304:333-338.
Yan, X., Mohankumar, P.S., Dietzschold, B., Schnell, M.J. and Fu, Z.F. The glycoprotein determines the spreading pattern of different rabies virus strains in the CNS. J. Neurovirol. 8:345-52. 2002.
Wu, X., Gong, X., Foley H.D., Schnell, M.J. and Fu, Z.F. Both viral transcription and replication are reduced when the rabies virus nucleoprotein is not phosphorylated. J. Virol. 76:4153-4161. 2002.
Information on
additional publications by Dr. Fu can be found at PubMed
Books:
Fu, Z. F. (editor).
2005. The World of Rhabdoviruses. Elsivier Publisher. |
