What we do:
Explore pathogenesis of infectious diseases, using various pathologic techniques
Who does what:
Corrie Brown, DVM, PhD, DACVP - http://www.vet.uga.edu/vpp/Brown/
Jian Zhang, Research Coordinator, chief organizer, runs the lab, trains the group
Leonardo Susta, DVM - Combined residency/PhD program, studying pathogenesis of Newcastle disease, http://www.vet.uga.edu/vpp/Brown/Lab/Susta.php
Janildo Reis, DVM, MS - Combined residency/PhD program, studying pathogenesis of vesicular stomatitis virus in cattle, http://www.vet.uga.edu/vpp/Brown/Lab/Reis.php
Raquel Rech, DVM, MS, PhD - Residency training, studying diagnosis and pathogenesis of rabies in various species, http://www.vet.uga.edu/vpp/Brown/Lab/Rech.php
Lindsay Stein - undergraduate student, Honors Biology and pre-vet, expected date of graduation May 2010, studying diagnostics of rabies
Caroline Colden - undergraduate student, Honors Microbiology and pre-med, expected date of graduation, May 2011, studying cell markers and vesicular stomatitis
Techniques used in our laboratory:
Immunohistochemistry - For finding a specific antigen within a histologic section. Here is an example. This is a section of brain from a guinea pig infected with Nipah virus. Using an antibody specific for Nipah virus, it is possible to see exactly what cells are infected (Nipah appears as the red dots):
In situ hybridization - For finding a specific segment of nucleic acid within a histologic section. Here is an example - Using a labeled segment of RNA that corresponds exactly to part of the genome of Newcastle disease, the virus can be seen to be replicating in Purkinje cells of the cerebellum (blue-black staining):
PCR from histologic sections
Laser Capture Microdissection
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