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Xiaoqin Ye, M.D., Ph.D.
Assistant Professor
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Department of Physiology and Pharmacology
College of Veterinary Medicine
Room 2227
University of Georgia
Athens, GA 30602
Phone (706) 542-6745
Lab (706) 542-6041
Fax (706) 542-3015
ye@uga.edu |
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 RESEARCH INTERESTS
There are two primary focuses in my laboratory: lysophospholipid signaling in reproduction, and reproductive toxicology. See also the UGA Interdisciplinary Toxicology Program Web site.
Lysophospholipids (LPs) were originally recognized as quantitatively minor phospholipids in the biosynthesis of cell membranes. These simple phospholipids contain a glycerophosphate or sphingoid backbone and single acyl chain of varied length and saturation. The signaling properties of LPs began to surface in 1960s.
Two prominent signaling LPs are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). LPA and S1P activate G protein-coupled receptors (GPCRs). To date, ten LP receptors have been identified, LPA1-5 and S1P1-5. Several LP receptors have been functionally deleted in the mice. Data from LP receptor(s) knockout mice have revealed the functions of LP signaling in numerous systems, such as the cardiovascular, nervous, immune, and reproductive systems. A collaborative study with Dr. Jerold Chun at The Scripps Research Institute has demonstrated that LP signaling is involved in embryo implantation and spacing in females as well as spermatogenesis in males. Our ongoing collaboration continues the investigation on the mechanisms of LP signaling in reproduction using the LP receptor(s) knockout mouse models.
In addition to the signaling mechanism studies in embryo implantation and spermatogenesis, the responses of these reproductive processes to environmental toxicants will also be explored.
PUBLICATIONS
Kotaro Hama, Junken Aoki, Tomoko Endo, Asuka Inoue, Tomokazu Amano, Motomu Kanai, Masakatsu Shibasaki, Xiaoqin Ye, Hiroshi Suzuki, Norio Matsuki, Jerold Chun, and Hiroyuki Arai. 2007 LPA3-mediated lysophosphatidic acid signaling independently regulates both embryo spacing and implantation. Biology of Reproduction, in press.
Xiaoqin Ye *, Kotaro Hama *, James J.A. Contos, Brigitte Anliker, Asko Inoue, Michael K. Skinner, Hiroshi Suzuki, Tomokazu Amano, Grace Kennedy, Hiroyuki Arai, Junken Aoki, and Jerold Chun. 2005 LPA3-mediated lysophosphatidic acid signalling in implantation and embryo spacing. Nature, 435(7038):104-8 (2005) (Comment in: Nature. 2005 May 5; 435(7038): 34-5.) * equal authorship.
Hongbin Li, Xiaoqin Ye, Chitladda Mahanivong, Dafang Bian, Jerold Chun, and Shuang Huang. 2005 Signaling mechanism responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. Journal of Biological Chemistry, 280(11): 10564-71.
Isao Ishii, Nubuyuki Fukushima, Xiaoqin Ye, and Jerold Chun. 2004 Lysophospholipid receptors: Signaling and biology. Annual Review of Biochemistry, 73: 321-54.
Marcy A. Kingsbury, Steven K. Rehen, Xiaoqin Ye, and Jerold Chun. 2004 Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. Journal of Cellular Biochemistry. 92(5):1004-12.
Xiaoqin Ye, Isao Ishii, Marcy A. Kingsbury, and Jerold Chun. 2002 Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta, 1585: 108-113.
James J.A. Contos, Xiaoqin Ye, Valerie P. Sah, and Jerold Chun. 2002 Tandem genomic arrangement and coexpression of a G protein (Gna15) and G protein-coupled receptor (s1p4/lpC1/Edg6) gene. FEBS Letters, 531: 99-102.
Xiaoqin Ye, Nubuyuki Fukushima, Marcy A. Kingsbury, and Jerold Chun. 2002 Lysophosphatidic acid in neural signaling. Neuroreport, 13(17): 2169-75.
James J.A. Contos, Isao Ishii, Nobuyuki Fukushima, Marcy A. Kingsbury, Xiaoqin Ye, Shuji Kawamura, Joan Heller Brown, and Jerold Chun. 2002 Characterization of LPA2 (EDG-4) and LPA1/LPA2 (EDG-2/EDG-4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to LPA2. Molecular and Cellular Biology, 22(19): 6921-9.
Nobuyuki Fukushima, Xiaoqin Ye, and Jerold Chun. 2002 Neurobiology of lysophosphatidic acid signalling. The Neuroscientist, 8(6): 540-50.
Isao Ishii, Xiaoqin Ye, Beth Friedman, Shuji Kawamura, James J.A. Contos, Marcy Kingsbury, Amy H. Yang, Guangfa Zhang, Joan Heller Brown, and Jerold Chun. 2002 Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. Journal of Biological Chemistry, 277(28): 25152-9.
Jean Wang *, Xiaoqin Ye *, Christy R. Muhlenkamp, and Sarjeet S. Gill. 2002 Effect of a Peroxisome Proliferator on 3-ß Hydroxysteroid Dehydrogenase. Biochemical and Biophysical Research Communications, 293(1):549-53. * equal authorship.
Isao Ishii, Beth Friedman, Xiaoqin Ye, Shuji Kawamura, Christine McGiffert, James J.A. Contos, Marcy Kingsbury, Guangfa Zhang, Joan Heller Brown, and Jerold Chun. 2001 Selective loss of sphingosine-1-phosphate (S1P) signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. Journal of Biological Chemistry, 276(36): 33697-704.
Xiaoqin Ye, Liming Lu and Sarjeet S. Gill. 1997 Suppression of Cytochrome p450 cyp2f2 mRNA levels in mice by the peroxisome proliferator diethylhexyl phthalate. Biochemical and Biophysical Research Communications 239: 660-5.
Rongyu Jin, Xiaoqin Ye, Zhiming Lei and Bin Xue. 1992 Immunotoxicity in mice exposed to benzene inhalation. China Environmental Science 12(4), 304-7.
Xiaoqin Ye, Rongyu Jin, Zhiming Lei and Bin Xue. 1991 Effect of benzene in workers at lower concentration on immune system. Chinese Journal of Public Health 10(6), 353-4.
EDUCATION
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