The University of Georgia College of Veterinary Medicine

Viral Immunology: Tripp Laboratory

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2008

Driskell JD, Shanmukh S, Liu Y, Chaney SB, Tang XJ, Zhao YP, and Dluhy RA. The use of aligned silver nanorod arrays prepared by oblique angle vapor deposition as SERS substrates. J. Phys. Chem. C. 2008;112:895.

Driskell J, Shanmukh S, Liu YJ, Hennigan S, Jones LJ, Zhao YP, Dluhy RA, Krause DC, and Tripp, RA. Infectious agent detection with SERS-active silver nanorod arrays prepared by oblique angle deposition. IEEE, Nanosensors for Defense & Security. 2008, in press.

Fu J, Jones LJ, Tripp RA, and Zhao YP. Au/Si hetero-nanorod-based biosensor for Salmonella detection. Nanotechnology. 2008, in press.

Murawski MR, Bowen GN, Cerny AM, Anderson LJ, Haynes LM, Tripp RA, Kurt-Jones EA, and Finberg RW. RSV activates innate immunity through Toll Like Receptor 2. J. Virol. 2008, in press.

Shanmukh S, Jones L , Zhao YP, Driskell JD, Tripp RA, and Dluhy RA. Identification and classification of respiratory syncytial virus (RSV) strains by surface enhanced Raman spectroscopy and multivariate statistical techniques. Anal. Bioanal. Chem. 2008 Mar;390(6):1551-5. Epub 2008 Jan 31.

Tripp RA and Tompkins SM. Perspectives on the immunobiology of influenza virus. Research Signpost: Chapters 1, 4, 9 and 14. March 2008, in press.

Tripp RA and Tompkins SM. Current Topics in Microbiology and Immunology: Vaccines for Pandemic Influenza. Springer Publications. March 2008, in press.

Tripp RA and Tompkins SM. Virally-Encoded MicroRNA (miRNA): Candidates for Gene Silencing. CRC Press. April 2008, in press.

Tripp RA and Tompkins SM. Therapeutic applications of RNAi for silencing virus replication. Humana Press. May 2008, in press.

Zhao YP and Tripp RA. Nanomaterials for the Life Sciences: Spherical and anisotropic silver nanomaterials in medical diagnosis. July 2008, in press.

Zhao YP, Dluhy RA, and Tripp RA. Novel nanostructures for surface-enhanced Raman spectroscopy (SERS) biosensing. NanoToday. 2008, in press.

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2007

Birkness KA, Guarner J, Sable SB, Tripp RA, Kellar KL, Bartlett J, and Quinn FD. An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection. Immunol Cell Biol. 2007 Feb-Mar;85(2):160-8. Epub 2007 Jan 2.

Driskell JD, Uhlenkamp JM, Lipert RJ, and Porter MD. Surface-enhanced Raman scattering immunoassays using a rotated capture substrate. Anal. Chem. 2007 Jun 1;79(11):4141-8. Epub 2007 May 8.

Ribeiro LZ, Tripp RA, Rossi LM, Palma PV, Yokosawa J, Mantese OC, Oliveira TF, Nepomuceno LL, and Queiróz DA. Serum mannose-binding lectin levels are linked with respiratory syncytial virus (RSV) disease. J Clin Immunol. 2008 Mar;28(2):166-73. Epub 2007 Oct 20.

Tripp RA, Alvarez R, Anderson B, Jones L, Weeks C, Chen W. Bioconjugated nanoparticle detection of respiratory syncytial virus infection. Int J Nanomedicine. 2007;2(1):117-24.

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2006

Agrawal A, Zhang C, Byassee T, Tripp RA, and Nie S. Counting single native biomolecules and intact viruses with color-coded nanoparticles. Anal Chem. 2006 Feb 15;78(4):1061-70.

Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, and Tripp RA. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. J Immunol. 2006 Feb 1;176(3):1600-8.

Li XQ, Fu ZF, Alvarez R, Henderson C, and Tripp RA. Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein. J.Virol. 2006 Jan;80(1):537-40.

Mahalingam S and Tripp RA. Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections? Microbes Infect. 2006 Jan;8(1):285-93. Epub 2005 Aug 10. Review.

Shanmukh S, Jones L, Driskell J, Zhao Y, Dluhy R, and Tripp RA. Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate. Nano Lett. 2006 Nov;6(11):2630-6.

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2005

Agrawal A, Tripp RA, Anderson LJ, and Nie S. Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes. J Virol. 2005 Jul;79(13):8625-8.

Alvarez R and Tripp RA. The immune response to human metapneumovirus (HMPV) is associated with an aberrant immunity and imparied virus clearance in BALB/c mice. J. of Virol. 2005 May;79(10):5971-8.

Seal BS, Wise MG, Pedersen JC, Senne DA, Alvarez R, Scott MS, King DJ, Yu Q, and Kapczynski DR. Genomic sequences of low-virulence avian paramyxovirus-1 (Newcastle disease virus) isolates obtained from live-bird markets in North America not related to commonly utilized commercial vaccine strains. Vet Microbiol. 2005 Mar 20;106(1-2):7-16. Epub 2005 Jan 28.

Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, Jones LP, Yilla M, Babcock GJ, Greenough T, Ambrosino DM, Alvarez R, Callaway J, Cavitt S, Kamrud K, Alterson H, Smith J, Harcourt JL, Miao C, Razdan R, Comer JA, Rollin PE, Ksiazek TG, Sanchez A, Rota PA, Bellini WJ, and Anderson LJ. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. J Virol Methods. 2005 Sep;128(1-2):21-8.

Tripp RA, Oshansky C, and Alvarez R. Cytokines and respiratory syncytial virus infection. Proc Am Thorac Soc. 2005;2(2):147-9. Review.

Tumpey TM, Suarez D, Alvarez R, and Swayne DE. Diagnostic approach for differentiating infected from vaccinated poultry on the basis of antibodies to NS1, the nonstructural protein of influenza A virus. J. Clin. Microbiol. 2005 Feb;43(2):676-83.

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2004

Alvarez R, Harrod KS, Shieh WJ, Zaki S, and Tripp RA. Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies. J Virol. 2004 Dec;78(24):14003-11.

Alvarez R, Jones LP, Seal BS, Kapczynski DR, and Tripp RA. Serological cross-reactivity of members of the Metapneumovirus genus. Virus Res. 2004 Sep 15;105(1):67-73. Erratum in: Virus Res. 2005 Jan;107(1):109.

Alvarez R, Njenga MK, Scott M, and Seal BS. Development of a nucleoprotein-based enzyme-linked immunosorbent assay utilizing a synthetic peptide antigen for detection of avian metapneumovirus in turkey sera. Clin. Diagn. Lab. Immuno. 2004 Mar;11(2):245-9.

Harcourt JL, Anderson LJ, Sullender W, and Tripp RA. Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particles. Vaccine. 2004 Jun 2;22(17-18):2248-60.

Harcourt JL, Karron RA, and Tripp RA. Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis. J Infect Dis. 2004 Dec 1;190(11):1936-40. Epub 2004 Oct 28.

Lwamba HCM, Alvarez R, Wise M, Yu Q, Halvorson D, Njenga MK, and Seal BS. Comparison of the full-length genome sequence of Avian metapneumovirus subtype C with other paramyxoviruses. Virus Res. 2005 Jan;107(1):83-92.

Tripp RA. Pathogenesis of respiratory syncytial virus infection. Viral Immunol. 2004;17(2):165-81. Review.

Tripp RA. The brume surrounding respiratory syncytial virus persistence. Am J Respir Crit Care Med. 2004 Apr 1;169(7):778-9.

Wise MG, Sellers HS, Alvarez R, and Seal BS. RNA-dependent RNA polymerase gene analysis of worldwide Newcastle disease virus isolates representing different virulence types and their phylogenetic relationship with other members of the Paramyxoviridae. Virus Res. 2004 Aug;104(1):71-80.

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2003

Alvarez R, Lwamba HM, Kapczynski DR, Njenga MK, and Seal BS. Nucleotide and predicted amino acid sequence-based analysis of the avian metapneumovirus type C cell attachment glycoprotein gene: phylogenetic analysis and molecular epidemiology of U. S. pneumoviruses. J. Clin. Microbiol. 2003 Apr;41(4):1730-5.

Harcourt JL, Brown MP, Anderson LJ, Tripp RA. CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice. Vaccine. 2003 Jun 20;21(21-22):2964-79.

Haynes LM, Jones LP, Barskey A, Anderson LJ, Tripp RA. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. J Virol. 2003 Sep;77(18):9831-44.

Henderson SC and Bamezai A. Loss of Ly-6A.2 expression on immature developing T cells inthe thymus is necessary for their normal growth and generation of the Vbeta T-cell repertoire. Tissue Antigens. 2003 Aug;62(2):117-32.

Jacobs JA, Njenga MK, Alvarez R, Mawditt K, Britton P, Cavanagh D, and Seal BS. Subtype B avian metapneumovirus resembles subtype A more closely than subtype C or human metapneumovirus with respect to the phosphoprotein, second matrix, and small hydrophobic proteins. Virus Res. 2003 Apr;92(2):171-8.

Tripp RA. Role of cytokines in the development and maintenance of memory T cells during respiratory viral infection. Curr Pharm Des. 2003;9(1):51-9. Review.

Tripp RA, Dakhama A, Jones LP, Barskey A, Gelfand EW, and Anderson LJ. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. J Virol. 2003 Jun;77(11):6580-4.

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2002

Haynes LM, Tonkin J, Anderson LJ, Tripp RA. Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection. J Virol. 2002 Jul;76(14):6873-81.

Henderson SC, Kamdar M, and Bamezai A. Ly-6A.2 expression regulates antigen-specific CD4+ T cell proliferation and cytokine production. J. Immunol. 2002 Jan 1;168(1):118-26.

Tripp RA, Barskey A, Goss L, and Anderson LJ. Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection. J. Neuroimmunol. 2002 Aug;129(1-2):141-53.

Tripp RA, Moore D, Barskey A, Jones L, Moscatiello C, Keyserling H, and Anderson LJ. Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. J Infect Dis. 2002 May 15;185(10):1388-94. Epub 2002 Apr 30.

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2001

Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, and Tripp RA. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 2001 Nov;75(22):10730-7.

Tripp RA, Hou S, Etchart N, Prinz A, Moore D, Winter J, and Anderson LJ. CD4(+) T cell frequencies and Th1/Th2 cytokine patterns expressed in the acute and memory response to respiratory syncytial virus I-E(d)-restricted peptides. Cell Immunol. 2001 Jan 10;207(1):59-71.

Tripp RA, Jones LP, Haynes LM, Zheng H, Murphy PM, and Anderson LJ. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat Immunol. 2001 Aug;2(8):732-8.

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2000

Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, and Finberg RW. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000 Nov;1(5):398-401.

Tripp RA, Jones L, and Anderson LJ. Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse. J Virol. 2000 Jul;74(13):6227-9.

Tripp RA, Jones L, Anderson LJ, Brown MP. CD40 ligand (CD154) enhances the Th1 and antibody responses to respiratory syncytial virus in the BALB/c mouse. J Immunol. 2000 Jun 1;164(11):5913-21.

Tripp RA, Moore D, and Anderson LJ. TH(1)- and TH(2)-TYPE cytokine expression by activated t lymphocytes from the lung and spleen during the inflammatory response to respiratory syncytial virus. Cytokine. 2000 Jun;12(6):801-7.

Tripp RA, Moore D, Winter J, Anderson LJ. Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice. J Virol. 2000 Feb;74(4):1614-22.

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1999

Brown MP, Nosaka T, Tripp RA, Brooks J, van Deursen JM, Brenner MK, Doherty PC, and Ihle JN. Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. Blood 1999 Sep 15;94(6):1906-14.

Tripp RA, Moore D, Jones L, Sullender W, Winter J, Anderson LJ. Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol. 1999 Sep;73(9):7099-107.

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1998

Colson YL, Tripp RA, Doherty PC, Wren SM, Neipp M, Abou El-Ezz AY, Ildstad ST. Antiviral cytotoxic activity across a species barrier in mixed xenogeneic chimeras: functional restriction to host MHC. J Immunol. 1998 Apr 15;160(8):3790-6.

Henderson SC, Berezovskaya A, English A, Palliser D, Rock KL, and Bamezai A. CD4+ T cells mature in the absence of MHC Class I and Class II expression in Ly-6A.2 transgenic mice. J. Immunol. 1998 Jul 1;161(1):175-82.

Tollefson AE, Hermiston TW, Lichtenstein DL, Colle CF, Tripp RA, Dimitrov T, Toth K, Wells CE, Doherty PC, and Wold WS. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature 1998 Apr 16;392(6677):726-30.

Tripp RA and Anderson LJ. Cytotoxic T-lymphocyte precursor frequencies in BALB/c mice after acute respiratory syncytial virus (RSV) infection or immunization with a formalin-inactivated RSV vaccine. J Virol. 1998 Nov;72(11):8971-5.

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1997

Doherty PC, Topham DJ, Tripp RA, Cardin RD, Brooks JW, and Stevenson PG. Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections. Immunol Rev. 1997 Oct;159:105-17. Review.

Doherty PC, Tripp RA, Hamilton-Easton AM, Cardin RD, Woodland DL, and Blackman MA. Tuning into immunological dissonance: an experimental model for infectious mononucleosis. Curr Opin Immunol. 1997 Aug;9(4):477-83. Review.

Mo XY, Sangster MY, Tripp RA, and Doherty PC. Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene. J Virol. 1997 Mar;71(3):2518-21.

Mo XY, Tripp RA, Sangster MY, and Doherty PC. The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon. J Virol. 1997 Mar;71(3):1906-10.

Topham DJ, Tripp RA, and Doherty PC. CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. J Immunol. 1997 Dec 1;159(11):5197-200.

Tripp RA, Hamilton-Easton AM, Cardin RD, Nguyen P, Behm FG, Woodland DL, Doherty PC, and Blackman MA. Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen? J Exp Med. 1997 May 5;185(9):1641-50.

Tripp RA, Topham DJ, Watson SR, and Doherty PC. Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. J Immunol. 1997 Apr 15;158(8):3716-20.

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1996

Doherty PC, Topham DJ, and Tripp RA. Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory. Immunol Rev. 1996 Apr;150:23-44. Review.

Sarawar SR, Cardin RD, Brooks JW, Mehrpooya M, Tripp RA, and Doherty PC. Cytokine production in the immune response to murine gammaherpesvirus 68. J Virol. 1996 May;70(5):3264-8.

Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, and Ihle JN. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996 Apr 18;380(6575):630-3.

Sparer TE, Tripp RA, Dillehay DL, Hermiston TW, Wold WS, and Gooding LR. The role of human adenovirus early region 3 proteins (gp19K, 10.4K, 14.5K, and 14.7K) in a murine pneumonia model. J Virol. 1996 Apr;70(4):2431-9.

Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, and Ihle JN. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996 Jul 11;382(6587):171-4.

Thomson SA, Elliott SL, Sherritt MA, Sproat KW, Coupar BE, Scalzo AA, Forbes CA, Ladhams AM, Mo XY, Tripp RA, Doherty PC, Moss DJ, and Suhrbier A. Recombinant polyepitope vaccines for the delivery of multiple CD8 cytotoxic T cell epitopes. J Immunol. 1996 Jul 15;157(2):822-6.

Topham DJ, Tripp RA, Hamilton-Easton AM, Sarawar SR, and Doherty PC. Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig. J Immunol. 1996 Oct 1;157(7):2947-52.

Topham DJ, Tripp RA, Sarawar SR, Sangster MY, and Doherty PC. Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium. J Virol. 1996 Feb;70(2):1288-91.

Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, and Ihle JN. Defective lymphoid development in mice lacking Jak3. Science. 1995 Nov 3;270(5237):800-2. Erratum in: Science. 1996 Jan 5;271(5245):17.

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1995

Tripp RA, Hou S, and Doherty PC. Temporal loss of the activated L-selectin-low phenotype for virus-specific CD8+ memory T cells. J Immunol. 1995 Jun 1;154(11):5870-5.

Tripp RA, Hou S, McMickle A, Houston J, and Doherty PC. Recruitment and proliferation of CD8+ T cells in respiratory virus infections. J Immunol. 1995 Jun 1;154(11):6013-21.

Tripp RA, Lahti JM, and Doherty PC. Laser light suicide of proliferating virus-specific CD8+ T cells in an in vivo response. J Immunol. 1995 Oct 15;155(8):3719-21.

Tripp RA, Sarawar SR, and Doherty PC. Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene. J Immunol. 1995 Sep 15;155(6):2955-9.

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1994

Doherty PC, Hou S, and Tripp RA>. CD8+ T-cell memory to viruses. Curr Opin Immunol. 1994 Aug;6(4):545-52. Review.

Doherty PC, Tripp RA, and Sixbey JW. Evasion of host immune responses by tumours and viruses. Ciba Found Symp. 1994;187:245-56; discussion 256-60. Review.

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1993

Hermiston TW, Tripp RA, Sparer T, Gooding LR, and Wold WS. Deletion mutation analysis of the adenovirus type 2 E3-gp19K protein: identification of sequences within the endoplasmic reticulum lumenal domain that are required for class I antigen binding and protection from adenovirus-specific cytotoxic T lymphocytes. J Virol. 1993 Sep;67(9):5289-98.

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1989

Maule AG, Tripp RA, Kaattari SL, and Schreck CB. Stress alters immune function and disease resistance in chinook salmon (Oncorhynchus tshawytscha). J Endocrinol. 1989 Jan;120(1):135-42.

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1987

Tripp RA, Maule AG, Schreck CB, and Kaattari SL. Cortisol mediated suppression of salmonid lymphocyte responses in vitro. Dev Comp Immunol. 1987 Summer;11(3):565-76.

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1986

Kaattari SL, Irwin MJ, Yui MA, Tripp RA, and Parkins JS. Primary in vitro stimulation of antibody production by rainbow trout lymphocytes. Vet Immunol Immunopathol. 1986 Jun;12(1-4):29-38.

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This page last updated May 16, 2008 .