The University of Georgia College of Veterinary Medicine

Jamie Barber - Tripp Lab, UGA

Viral Immunology: Tripp Laboratory

Jamie Barber

barber@uga.edu

Animal Health Research Center, Room 112A

Office: (706) 542-4092

Cytometry Lab: (706) 542-9807

The AHRC Cell Imaging Facility: http://www.vet.uga.edu/ahrc/imaging/

Education

BA Biology. St. Mary's College of Maryland

MSc Environmental Science. The Johns Hopkins University

Research Interests

Currently, I am working to expand the cell imaging facility located in the Animal Health Research Center. This resource includes a state-of-the-art confocal microscope (Zeiss Axio Imager M1 with LSM 510 Meta), two analytical flow cytometer instruments (BD LSR-II and Luminex X200), two state-of-the-art high-speed cell sorters (a BD Aria-II SORP and BD Influx), and a high-content / high-throughput acquisition and analysis system for the study of tissues and plate-based specimens (Cellomics vTi). One of my main objectives is to educate students and fellow scientists in how to best use these powerful technologies.

My interests include the development of novel assays to assess the interplay of zoonotic viruses with host immune function using microscopic, flow cytometric, multiplexed bead-based and quantum dot technologies.

Additionally, I hope to develop a flow cytometry-based in-vitro diagnostic service available to the UGA and surrounding Vet Med communities. In collaboration with clinical faculty at the Teaching Hospital, we hope to develop and validate tools to aid in the rapid diagnosis of hematopoetic neoplasias and viral infections.

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Publications

Search PubMed for Barber, J

Oshansky CM, Barber JP, Crabtree J,and Tripp R. Respiratory Syncytial Virus (RSV) F and G Proteins Induce IL-1 alpha, CC and CXC Chemokine Responses by Normal Human Bronchoepithelial Cells. J Infect Dis. 2010 Mar 5. [Epub ahead of print]

Sharrow AC, Ronnett BM, Thoburn CJ, Barber JP, Giuntoli RL II, Armstrong DK, Jones RJ, and Hess AD. Identification and characterization of a spontaneous ovarian carcinoma in Lewis rats. Journal of Ovarian Research. In press.

Sun HY, Noe J, Barber J, Coyne RS, Cassidy-Hanley D, Clark TG, Findly RC, and Dickerson HW. Endosymbiotic bacteria in the parasitic ciliate Ichthyophthirius multifiliis. Appl Environ Microbiol. 2009 Dec;75(23):7445-52. Epub 2009 Oct 9.

Oshansky CM, Krunkosky TM, Barber J, Jones LP, and Tripp RA. Respiratory syncytial virus proteins modulate suppressors of cytokine signaling 1 and 3 and the type I interferon response to infection by a toll-like receptor pathway. Viral Immunol. 2009 Jun;22(3):147-61.

Jones RJ, Gocke CD, Kasamon YL, Miller CB, Perkins B, Barber JP, Vala MS, Gerber JM, Gellert LL, Siedner M, Lemas MV, Brennan S, Ambinder RF, and Matsui W. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood. 2009 Jun 4;113(23):5920-6. Epub 2009 Feb 2.

Savage WJ, Barber JP, Mukhina GL, Hu R, Chen G, Matsui W, Thoburn C, Hess AD, Cheng L, Jones RJ, and Brodsky RA. Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH. Exp Hematol. 2009 Jan;37(1):42-51. Epub 2008 Nov 14.

Moore EC, Barber J, and Tripp RA. Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15). Virol J. 2008 Oct 13;5:116.

Matsui W, Wang Q, Barber JP, Brennan S, Smith BD, Borrello I, McNiece I, Lin L, Ambinder RF, Peacock C, Watkins DN, Huff CA, and Jones RJ. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008 Jan 1;68(1):190-7.

Lin TL, Vala MS, Barber JP, Karp JE, Smith BD, Matsui W, and Jones RJ. Induction of acute lymphocytic leukemia differentiation by maintenance therapy. Leukemia. 2007 Sep;21(9):1915-20. Epub 2007 Jul 5.

McNiece I, Civin C, Harrington J, Kellner J, Malehorn M, Turney J, Barber J, and Jones R. Ex vivo expansion of mafosfamide-purged PBPC products. Cytotherapy 2006;8(5):459-64.

Murata S, Kominsky SL, Vali M, Zhang Z, Garrett-Mayer E, Korz D, Huso D, Baker SD, Barber J, Jaffee E, Reilly RT, and Sukumar S. Ductal access for prevention and therapy of mammary tumors. Cancer Res. 2006 Jan 15;66(2):638-45.

Hu R, Mukhina GL, Piantadosi S, Barber JP, Jones RJ, and Brodsky RA. PIG-A mutations in normal hematopoiesis. Blood 2005 May 15;105(10):3848-54. Epub 2005 Feb 1.

Angstreich GR, Matsui W, Huff CA, Vala MS, Barber J, Hawkins AL, Griffin CA, Smith BD, and Jones RJ. Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors. Br J Haematol. 2005 Aug;130(3):373-81.

Matsui WH, Huff CA, Wang Q, Malehorn MT, Barber J, Tanhehco Y, Smith BD, Civin CI, and Jones RJ. Characterization of clonogenic multiple myeloma cells. Blood 2004 Mar 15;103(6):2332-6. Epub 2003 Nov 20.

Matsui W, Huff CA, Vala M, Barber J, Smith BD, and Jones RJ. Anti-tumour activity of interferon-alpha in multiple myeloma: role of interleukin 6 and tumor cell differentiation. Br J Haematol. 2003 Apr;121(2):251-8.

Matsui WH, Gladstone DE, Vala MS, Barber JP, Brodsky RA, Smith BD, and Jones RJ. The role of growth factors in the activity of pharmacological differentiation agents. Cell Growth & Differentiation 2002 Jun;13(6):275-83.

Mukhina GL, Buckley JT, Barber JP, Jones RJ, and Brodsky RA. Multilineage glycosylphosphatidylinositol anchor-deficient haematopoiesis in untreated aplastic anaemia. Br J Haematol. 2001 Nov;115(2):476-82.

Smith BD, Bambach BJ, Vala MS, Barber JP, Enger C, Brodsky RA, Burke PJ, Gore SD, and Jones R. Inhibited apoptosis and drug resistance in acute myeloid leukemia. Br. J. Haematol. 1998 Sep;102(4):1042-9.

Sharkis SJ, Collector MI, Barber JP, Vala MS, and Jones RJ. Phenotypic and functional characterization of the hematopoietic stem cell. Stem Cells 1997;15 Suppl 1:41-4; discussion 44-5.

Brodsky RA, Vala MS, Barber JP, Medof ME, and Jones RJ. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proc. Natl. Acad. Sci. USA, 1997 Aug 5;94(16):8756-60.

Jones RJ, Collector MI, Barber JP, Vala MS, Fackler MJ, May WS, Griffin CA, Hawkins AL, Zehnbauer BA, Hilton J, Colvin OM, and Sharkis SJ. Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity. Blood 1996 Jul 15;88(2):487-91.

Bedi A, Pasricha PJ, Akhtar AJ, Barber JP, Bedi GC, Giardiello FM, Zehnbauer BA, Hamilton SR, and Jones RJ. Inhibition of apoptosis during development of colorectal cancer. Cancer Res. 1995 May 1;55(9):1811-6.

Bedi A, Barber JP, Bedi GC, El Deiry WS, Sidransky D, Vala MS, Akhtar AJ, Hilton J, and Jones RJ. BCR-ABL-mediated inhibition of apoptosis by delay of G2/M transition following DNA damage: a mechanism of resistance to multiple anticancer agents. Blood 1995 Aug 1;86(3):1148-58.

Jones RJ, Barber JP, Vala MS, Collector MI, Kaufmann SH, Ludeman SM, Colvin OM, and Hilton J. Assessment of aldehyde dehydrogenase in viable cells. Blood 1995 May 15;85(10):2742-6.

Bedi A, Griffin CA, Barber JP, Vala MS, Hawkins AL, Sharkis SJ, Zehnbauer BA, and Jones RJ. Growth factor-mediated terminal differentiation of chronic myeloid leukemia. Cancer Res. 1994 Nov 1;54(21):5535-8.

Bedi A, Zehnbauer BA, Barber JP, Sharkis SJ, and Jones RJ. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 1994 Apr 15;83(8):2038-44.

Bedi A, Zehnbauer BA, Collector MI, Barber JP, Zicha MS, Sharkis SJ, and Jones RJ. BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. Blood 1993 Jun 1;81(11):2898-902.

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This page last updated November 8, 2011 .