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RALPH A. TRIPP Research interests include understanding the mechanisms of immunity and disease pathogenesis associated with respiratory virus infection, and using this information to develop therapeutic protocols and vaccines that will confer long-term protective immunity.
Professor, Georgia Research Alliance Chair of Animal Health Vaccine Development, GRA Eminent Scholar
RECENT PUBLICATIONS
Mahalingam, S., Schwarze, J., Zaid, A., Nissen, M., Sloots, T., Tauro, S., Storer, J., Alvarez, R. and Tripp, R. A. 2006. Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections? Microbes and Infection, 8(1):285-93.
Li, X. Q., Fu, Z. F., Alvarez, R., Henderson, C. and Tripp, R. A. 2006. Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein. Journal of Virology, 80(1):537-40.
Harcourt, J., Alvarez, R., Jones, L. P., Henderson, C., Anderson, L. J. and Tripp, R. A. 2006. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. Journal of Immunology, 176(3):1600-8.
Agrawal, A., Zhang, C., Byassee, T., Tripp, R. A. and Nie, S. 2006. Counting single native biomolecules and intact viruses with color-coded nanoparticles. Analytical Chemistry, 78(4):1061-70.
Tripp, R. A., Oshansky, C. and Alvarez, R. 2005. Cytokines and respiratory syncytial virus (RSV) infection. Proceedings of the American Thoracic Society, 2:147-149.
Tripp, R. A. et al. 2005. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. Journal of Virological Methods, 128:21-8.
Agrawal, A., Tripp, R. A., Anderson, L. J. and Nie, S. 2005. Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes. Journal of Virology, 79(13):8625-8.
Alvarez, R. and Tripp, R. A. 2005. The immune response to human metapneumovirus is associated with aberrant immunity and impaired virus clearance in BALB/c mice. Journal of Virology, 79(10):5971-8.
Alvarez, R., Harrod, K. S., Shieh, W. J., Zaki, S. and Tripp, R. A. 2004. Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies. Journal of Virology, 78(24):14003-11.
Harcourt, J. L., Karron, R. A. and Tripp, R. A. 2004. Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis. Journal of Infectious Diseases, 190(11):1936-40.
Alvarez, R., Jones, L. P., Seal, B. S., Kapczynski, D. R. and Tripp, R. A. 2004. Serological cross-reactivity of members of the Metapneumovirus genus. Virus Research, 105(1):67-73.
Tripp, R. A. 2004. Pathogenesis of respiratory syncytial virus infection. Viral Immunology, 17(2):165-81. Review.
Harcourt, J. L., Anderson L. J., Sullender W. and Tripp, R. A. 2004. Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particles. Vaccine, 22(17-18):2248-60.
Tripp, R. A. 2004. The brume surrounding respiratory syncytial virus persistence. American Journal of Respiratory and Critical Care Medicine, 169(7):778-9.
Haynes, L. M., Jones, L. P., Barskey, A., Anderson, L. J. and Tripp, R. A. 2003. Enhanced Disease and Pulmonary Eosinophilia Associated with Formalin-Inactivated Respiratory Syncytial Virus Vaccination Are Linked to G Glycoprotein CX3C-CX3CR1 Interaction and Expression of Substance P, Journal of Virology, S77(18):9831-44.
Tripp, R. A., Dakhama, A., Gelfand, E., and Anderson, L. J. 2003. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. Journal of Virology, 77:6580.
Harcourt, J. L., Brown M. P., Anderson L. J. and Tripp, R. A. 2003. CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice. Vaccine, 21:2964.
Tripp, R. A., 2003. Role of cytokines in the development and maintenance of memory T cells during respiratory viral infection, Current Pharmaceutical Design, 9:51.
Tripp, R. A., Barskey, A., Goss, L. and Anderson, L. J. 2002. Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection. Journal of Neuroimmunology, 129(1-2): 141-53.
Makela, M. J., Kanehiro, A., Dakhama, A., Borish, L., Joetham, A., Tripp, R. A., Anderson, L. J. and Gelfand, E. W. 2002. The failure of interleukin-10-deficient mice to develop airway hyper-responsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. American Journal of Respiratory and Critical Care Medicine, 165(6): 824-31.
Tripp, R. A., Moore, D., Barskey, A., Jones, L. P., Moscatiello, C., Keyserling, H. L. and Anderson, L. J. 2002. Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. Journal of Infectious Diseases, 185(10): 1388-94.
Haynes, L. M., Tonkin, J., Anderson, L. J. and Tripp, R. A. 2002. Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection. Journal of Virology, 76: 6873-6881.
Tripp, R. A., Jones, L. P., Haynes, L. M., Zheng, H., Murphy, P. M. and Anderson, L. J. 2001. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein, Nature Immunology, 2:732-738.
Tripp, R. A., Hao, S., Etchart, N., Prinz, A., Moore, D. and Anderson, L. J. 2001. CD4+ T cell frequencies and Th1/Th2 cytokine patterns expressed in the acute and memory response to respiratory syncytial virus I-E(d)-restricted peptides, Cellular Immunology, 207:59-71.
Haynes, L. M., Moore, D.,Kurt-Jones, E., Finberg, R. W., Anderson, L. J. and Tripp, R. A. 2001. Involvement of toll-like receptor-4 in innate immunity to respiratory syncytial virus. Journal of Virology, 75:10730-10737.
Tripp, R. A., Moore, D., Winter, J. and Anderson, L. J. 2000. Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P which mediates inflammation and enhanced pulmonary disease in BALB/c mice. Journal of Virology, 74:1614.
Tripp, R. A., Jones, L. P. and Anderson, L. J. 2000. Respiratory syncytial virus G and/or SH Glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse. Journal of Virology, 74:6227.
Tripp, R. A., Moore, D. and Anderson, L. J. 2000. Th1- and Th2-type cytokine expression by activated T lymphocytes from the lung and spleen during the inflammatory response to respiratory syncytial virus. Cytokine, 12:801, 2000.
Tripp, R. A., Jones, L. P., Anderson, L. J. and Brown, M. P. 2000. CD40 ligand (CD154) enhances the Th1 and antibody response to respiratory syncytial virus in the BALB/c mouse. Journal of Immunology, 164:5913.
Kurt-Jones, E. A., Popova, L., Kwinn, L., Tripp, R. A., Haynes, L., Jones, L. P., Walsh, E. E., Freeman, M., Golenbock, D., Anderson, L. J. and Finberg, R. 2000. The pattern recognition receptors TLR4 and CD14 mediate the innate immune response to respiratory syncytial virus fusion protein, Nature Medicine, 1:402.
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Email Office Tripp Lab Page Center for Disease Intervention Degrees
rtripp@vet.uga.edu
201 AHRC
706-542-1557
www.vet.uga.edu/id/tripp
www.uga.edu/cdi
PhD, Oregon State University, 1989